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Short regulatory peptides

Epitalon

A synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG).

Also known as Epithalon, AEDG peptide

Formula
C14H22N4O9
Average mass
390.346 Da
Length
4 residues
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Vial size

10 or 50 mg vials

Lot Loading the lot Record
  • Sealed, crimp-capped vial with its lot number on the label.
  • Orders are packed once payment clears.

Research use only. Epitalon is supplied as a laboratory reagent. It is not a drug, food, supplement or cosmetic, and it is not for human or veterinary use.

Lot record

Check the lot before you buy.

Purity is the main peak’s share of the HPLC signal. Identity is the mass the sequence predicts, next to the mass measured. Move along either trace to read it.

Certificate of analysis

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HPLC purity
Release minimum
99.0%
Mass, calculated
390.346 Da
Mass, observed
Difference
release rule: within ±1.0 Da
Tested
Laboratory
Method

How to read a certificate
HPLC RP · UV 220 nm

The chromatogram draws here from the lot’s numbers.

Mass spec ESI, positive

The mass spectrum draws here from the sequence and the lot’s numbers.

Every published lot

Published lots of Epitalon
LotTestedHPLC purityObserved mass, DaStatusCertificate

Overview

What it is.

Epitalon was designed in Russia from the amino-acid composition of epithalamin, a peptide extract of the pineal gland. It is a short, strongly acidic peptide with two carboxylic acid side chains.

It is studied in cell-culture research on telomerase activity and in animal studies.

We don’t summarize studies on product pages. Search PubMed for “Epitalon” (opens in a new tab)

Sequence & properties

Computed from the sequence.

A1E2 D3G4

Residue colors: Hydrophobic Polar Basic (+) Acidic (−) Non-standard

Three-letter sequence: H-Ala-Glu-Asp-Gly-OH

Open in Sequence Studio
Molecular formula
C14H22N4O9
Average mass
390.346 Da
Monoisotopic mass
390.1387 Da
Length
4 residues
Isoelectric point (pI)
3.55
Net charge at pH 7.0
−2.02
GRAVY (Kyte–Doolittle)
−1.400
Extinction coefficient, 280 nm
No Trp or Tyr: measure at 205–220 nm
Modifications
None (free N-terminus, free C-terminal acid)
CAS number
307297-39-8
Form
Lyophilized powder in a sealed glass vial
Purity
Measured per lot by HPLC: see the lot record

Calculated from the sequence with standard atomic weights and the EMBOSS pKa set, for the free peptide (not a salt form). The formula matches the NCATS Inxight Drugs entry (UNII O65P17785G) (opens in a new tab); the mass agrees with it to within 0.05 Da.

HydropathyKyte–Doolittle · per residue
−4−20+2+4+1.8−3.5−3.5−0.4AEDG↑ HYDROPHOBIC−4−20+2+4+1.8−3.5−3.5−0.4AEDG↑ HYDROPHOBIC−4−20+2+4+1.8−3.5−3.5−0.4AEDG↑ HYDROPHOBIC

Above zero is hydrophobic; below is polar or charged. Per residue: Ala +1.8, Glu −3.5, Asp −3.5, Gly −0.4. The average, −1.4, puts it on the polar side.

Storage & handling

Cold, dry and dark.

Sealed vial
Follow the released lot’s documented storage conditions and laboratory safety data.
In transit
Transport conditions must be supported for this material; ambient shipping is not assumed.
Before opening
Let the vial reach room temperature, so moisture doesn’t condense on the powder.
In solution
Use a validated in-vitro laboratory protocol. Stability depends on the compound, solvent and conditions; no general shelf life is promised.

Questions

Before you order.

All questions
How do I know what’s in the vial?

Every lot we sell has a certificate of analysis on file, showing HPLC purity and mass-spectrometry identity for that exact lot. It is linked on the product page before you buy.

The lot number printed on your vial opens the same record on our Verify page, so you can match the vial in your hand to its test results.

What does an HPLC purity figure tell me?

High-performance liquid chromatography separates a sample into its components. Purity is the main peak’s share of the total detected signal, usually measured by UV absorbance around 214–220 nm.

It measures the main component against peptide-related impurities; it isn’t net peptide content, which also accounts for water and counter-ions.

How do I pay, and when does my order ship?

The available payment methods are listed at checkout. A research request first enters review, with no payment due. Payment instructions appear only after verification and approval. Sample requests cannot be paid or fulfilled.

Orders are packed once payment clears. You can follow every step on the order page or with your order number on Track an order.

What does “research use only” mean?

Our peptides are supplied as laboratory reagents for research by qualified buyers. None is approved as a drug, food, supplement or cosmetic in the form we supply it, and none is for human or veterinary use.

We don’t give advice about using peptides in people or animals, and product pages describe what each compound is and how it is studied, never what it does to a person.

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Epitalon

10 mg vial