Render5 mg vial · front

Mitochondrial & metabolic signaling

MOTS-c

A 16-residue peptide encoded by a short open reading frame in the mitochondrial 12S rRNA gene.

Also known as Mitochondrial open reading frame of the 12S rRNA-c

Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Average mass: 2174.592 Da
Length: 16 residues

Sealed, crimp-capped vial with its lot number on the label.
Orders are packed once payment clears.

Research use only. MOTS-c is supplied as a laboratory reagent. It is not a drug, food, supplement or cosmetic, and it is not for human or veterinary use.

Lot record

Check the lot before you buy.

Purity is the main peak’s share of the HPLC signal. Identity is the mass the sequence predicts, next to the mass measured. Move along either trace to read it.

Certificate of analysis

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HPLC purity
Release minimum: 99.0%
Mass, calculated: 2174.592 Da
Mass, observed
Difference: release rule: within ±1.0 Da
Tested
Laboratory
Method

How to read a certificate

HPLC RP · UV 220 nm

The chromatogram draws here from the lot’s numbers.

Mass spec ESI, positive

The mass spectrum draws here from the sequence and the lot’s numbers.

Every published lot

Published lots of MOTS-c
Lot	Tested	HPLC purity	Observed mass, Da	Status	Certificate

Overview

What it is.

MOTS-c belongs to the small group of mitochondrial-derived peptides, which are encoded in mitochondrial DNA rather than the nuclear genome.

MRWQEMGYIFYPRKLR is the human sequence. It is studied in cell and rodent research on AMPK signaling.

We don’t summarize studies on product pages. Search PubMed for “MOTS-c” (opens in a new tab)

Sequence & properties

Computed from the sequence.

M1R2W3Q4E5M6G7Y8I9F10Y11P12R13K14 L15R16

Residue colors: Hydrophobic Polar Basic (+) Acidic (−) Non-standard

Three-letter sequence: H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH

Open in Sequence Studio

Molecular formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂
Average mass: 2174.592 Da
Monoisotopic mass: 2173.1077 Da
Length: 16 residues
Isoelectric point (pI): 10.64
Net charge at pH 7.0: +2.98
GRAVY (Kyte–Doolittle): −0.938
Extinction coefficient, 280 nm: 8,480 M⁻¹cm⁻¹
Modifications: None (free N-terminus, free C-terminal acid)
Form: Lyophilized powder in a sealed glass vial
Purity: Measured per lot by HPLC: see the lot record

Calculated from the sequence with standard atomic weights and the EMBOSS pKa set, for the free peptide (not a salt form). The formula matches the PubChem entry (CID 146675088) (opens in a new tab); the mass agrees with it to within 0.05 Da.

HydropathyKyte–Doolittle · window 7

Above zero is hydrophobic; below is polar or charged. Most hydrophobic stretch: residues 6–12 (average +0.7). Most polar: residues 2–8 (average −1.7). Windows above zero: 3 of 10.

Storage & handling

Cold, dry and dark.

Sealed vial: Follow the released lot’s documented storage conditions and laboratory safety data.
In transit: Transport conditions must be supported for this material; ambient shipping is not assumed.
Before opening: Let the vial reach room temperature, so moisture doesn’t condense on the powder.
In solution: Use a validated in-vitro laboratory protocol. Stability depends on the compound, solvent and conditions; no general shelf life is promised.

Solution Calculator Storage and handling guide

Questions

Before you order.

All questions

How do I know what’s in the vial?

Every lot we sell has a certificate of analysis on file, showing HPLC purity and mass-spectrometry identity for that exact lot. It is linked on the product page before you buy.

The lot number printed on your vial opens the same record on our Verify page, so you can match the vial in your hand to its test results.

What does an HPLC purity figure tell me?

High-performance liquid chromatography separates a sample into its components. Purity is the main peak’s share of the total detected signal, usually measured by UV absorbance around 214–220 nm.

It measures the main component against peptide-related impurities; it isn’t net peptide content, which also accounts for water and counter-ions.

What HPLC purity means

How do I pay, and when does my order ship?

The available payment methods are listed at checkout. A research request first enters review, with no payment due. Payment instructions appear only after verification and approval. Sample requests cannot be paid or fulfilled.

Orders are packed once payment clears. You can follow every step on the order page or with your order number on Track an order.

What does “research use only” mean?

Our peptides are supplied as laboratory reagents for research by qualified buyers. None is approved as a drug, food, supplement or cosmetic in the form we supply it, and none is for human or veterinary use.

We don’t give advice about using peptides in people or animals, and product pages describe what each compound is and how it is studied, never what it does to a person.